Some studies reported that up-regulated Ezrin was a negative prognostic factor for survival for cancer patients15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, However, other studies showed an opposite result48, 50, 51, 52, 78. This evidence concerns the gene EZR and cancer.