BRCA1 and ovarian cancer: Analysis of single-nucleotide polymorphism arrays using dedicated data-processing methods identified large-scale genomic instability25 and LOH26, 27 signatures similar to that of breast and ovarian cancers with BRCA1/2 inactivation in 91% (112/123; Fig. 2c) and 78% (96/123; Fig. 2d) of OS, respectively.