PTEN and cancer: Eight of these genes—BRCA2, BAP1, RET, MUTYH, ATM, PTEN, WRN and RECQL4—are well-known Mendelian cancer drivers, whilst the four remaining genes (ATRX, FANCA, NUMA1 and MDC1) have been reported in the context of cancer susceptibility2, 22, 23, 24.