Over expression of hsa-miR-195 down regulated and silencing of hsa-miR-195 by antimiR-195 up regulated the expression of ACACA, FASN and 3-Hydroxy-3-Methyl glutaryl CoA reductase (HMGCR), Cytochrome P450 family 27, subfamily B, polypeptide 1 (CYP27B1), a member of the cytochrome P450 superfamily respectively in breast cancer cells. This evidence concerns the gene CYP27B1 and breast carcinoma.