The score between Breast Cancer (MIM: 114480) and Noninsulin Dependent Diabetes (NDDIM) (MIM: 125853) lies in the 100th percentile, and several cancer related proteins are known to interact with NDDIM related proteins (TP53 – HNF4A, CDH1 – PTPN14, CDH1 – IRS1). This evidence concerns the gene IRS1 and type 2 diabetes mellitus.