Given its important role in sustaining the self-renewal and differentiation of Embryonic Stem CellS (ESCs)71, 72, 73, STAT3 is also evidently essential for regulating CSCs of cancers such as ovarian cancer74, HCC75, breast cancer76 colorectal cancer77, glioblastoma78, lung cancer79, and prostate cancer80. This evidence concerns the gene STAT3 and cancer.