For example, curcumin, a natural anti-inflammatory drug, protects mice from lipopolysaccharide (LPS)-induced brain inflammation and from progression of myelin oligodendrocyte glycoprotein (MOG) peptide-induced experimental autoimmune encephalomyelitis (EAE) upon intranasal administration in the form of curcumin-loaded EVs [71]. The gene discussed is MOG; the disease is brain inflammatory disease.