Given our previous observation that PWV was an independent predictor of preclinical atherosclerosis [11], we assessed effect of high-dose (3.36 g) omega-3 fatty acids on PWV and secondarily high sensitivity C-reactive protein (hsCRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), and serum adiponectin. This evidence concerns the gene PLA2G7 and atherosclerosis.