Given that the regulation of lipid influx, synthesis, and metabolism is disturbed in the liver of NAFLD patients, NAFLD is associated with dyslipidemia, which leads to an up-regulation of the sterol regulatory element binding protein-1c (SREBP-1c), a transcription factor for some de-novo lipogenesis genes, to inhibition of the free fatty acid (FFA) oxidation and stimulation of liver fat content (LFC) [35–37]. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.