The Ki-67 index was higher in carcinoma than in adenoma and hyperplasic areas (mean ± SD of 44 ± 15, 34 ± 12, and 25 ± 11 %, respectively) (Fig. 3c), and the cell density increased from W10 to W14 (Fig. 3d–f). Here, MKI67 is linked to adenoma.