Indeed, we have previously identified two mutations in the platelet P2Y12 ADP receptor gene (P2RY12) in patients with type 1 VWD who were recruited through the European Molecular and Clinical Markers for the Diagnosis and Management of type 1 von Willebrand Disease (MCMDM-1VWD) study and showed that they could contribute to the bleeding phenotype in these patients [7,8]. This evidence concerns the gene P2RY1 and von Willebrand disease 1.