MAPT and tauopathy: Brains from uninfected TauKO mice [24] were used to establish the background levels of T-Tau and P-Tau signaling in our system, while the Tau overexpressing JNPL3 mouse line, a well characterized transgenic model of tauopathy which has a P301L mutation in the Tau gene, and develops neurofibrillary tangles, was used as a positive control [25].