MAPT and scrapie: Of the scrapie-infected mouse brains, the amount of P-Tau was greatest in 139A followed by ME7 and then 22L, although the differences were not significant (p>0.05) when Mab CP13 was used for immunostaining, but were significant p<0.05) when Mab PHF1 was used to compare the three scrapie strains (Fig 2).