In addition, annexin V/PI staining showed that TAS-116 significantly enhanced apoptosis induced by these inhibitors in RAS-mutated MM cell lines (P < 0.01 in each combination treatment versus either monotherapy or control in NCI-H929 and MM.1S cell lines; P < 0.05 in each combination treatment versus either monotherapy or control in RPMI-8226 cell line; P < 0.01 in dabrafenib and AZD6244 combination treatment versus either monotherapy or control, and P < 0.01 in tipifarnib combination treatment versus monotherapy or control in INA6 cell line) (Fig 5A). The gene discussed is ANXA5; the disease is Miyoshi myopathy.