The frequency of 11q- CLL with associated mutations was 8/25 (32%) for SF3B1, 5/25 (20%) for NOTCH1, 4/25 (16%) for TP53, 2/25 (8%) for XPO1 and 1/25 (4%) for BIRC3. These mutations are shown in Fig 2 and listed in Table 5. Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.