The murine DC IL12 response can be altered depending on the biochemical composition of the parasite surface, as evidenced by a study demonstrating that infection with L. major LV39c5 lpg2−, a mutant that lacks phosphoglycan (PG)-containing molecules and other LPG2-dependent metabolites [31], induced IL12B in bone marrow derived mouse DCs (BMDCs) co-stimulated with anti-CD40 and IFNG [32]. Here, IL12B is linked to infection.