SOX17 and neoplasm: In two mouse models of implantable tumor growth and metastasis, tumor ECs were observed to express Sox17 at elevated levels; genetic deletion or over-expression of Sox17 was found to suppress or enhance, respectively, tumor growth and metastasis; and, in a small series, elevated levels of Sox17 were seen in tumor ECs in the majority of high grade human glioblastomas, but not in low grade glioblastomas or in normal brain tissue.