Thus, in the present study we focused on the role of the CRF system in the anterior-dorsal BNST (adBNST) containing the oval, anterodorsal, anterolateral and juxtacapsular nuclei (Fig. 1) (Dong et al., 2001b) in regulating maternal and anxiety-related behavior in lactating rats. The gene discussed is CRH; the disease is Anxiety.