Thus, given the lack of effect of CRF-R manipulation in the adBNST and a strong anxiolytic effect of CRF-R inhibition in the mpBNST of lactating rats (Klampfl et al., 2014), we propose that the anxiety-mediating effects of CRF might be restricted to the mpBNST during lactation. Here, CRHR1 is linked to Anxiety.