Interestingly, this is in contrast to the mpBNST (Klampfl et al., 2014) where inhibition of CRF-R2 has similar behavioral effects as inhibition of CRF-R1 in the adBNST suggesting that maternal care is differentially regulated by CRF-R in a site specific-manner: in the anterior BNST CRF-R1 seems to be the dominant receptor regulating maternal care, whereas in the posterior BNST CRF-R2 predominate in modulating maternal care and aggression as well as anxiety-related behavior (Klampfl et al., 2014). The gene discussed is CRHR1; the disease is Anxiety.