In the intestine, subsets of ILC1 are also cytokine producers (IFN-γ and TNF-α) after in vitro stimulation with IL-12 + IL-15 or IL-12+ IL-18 or after mucosal infection [22, 29, 50].They can also also degranulate after in vitro stimulation in the presence of tumor cell line [22]. The gene discussed is IL15; the disease is neoplasm.