ADM and chronic kidney disease: In this regard, the utility of midregional pro-adrenomedullin (MR-proADM), the midregional precursor of adrenomedullin (ADM) is of interest as it is an indicator for disease severity in a wide spectrum of cardiovascular disease states as well as various non-cardiovascular diseases including sepsis, COPD, pneumonia and chronic renal insufficiency [12–16].