CD19 and B-cell non-Hodgkin lymphoma: Since CD19 has been expressed in most B-cell NHL patients, denintuzumabmafodotin (SGN-CD19A) can be a novel antibody-drug conjugate consisting of a humanized anti-CD19 mAb attached to the microtubule-disrupting agent monomethyla-uristatin F (MMAF) through a maleimidocaproyl linker. SGN-CD19A has indicated signs of clinical activity with an objective response rate (ORR) of 40% (8 of 20 cases) and an observed complete response rate of 30% (6 of 20 cases).