Iniguez et al. 2004 [43] found no correlations between adiponectin and insulin levels at two years of life, However, Mami et al. 2008 [42] reported negative correlation between adiponectin and insulin at birth and Yamamoto et al. 2002 [44] reported negative correlations between adiponectin and insulin in adults and that serum adiponectin concentration predicts subsequent changes in insulin resistance. This evidence concerns the gene ADIPOQ and Insulin resistance.