The long-term use anti-obesity drugs are orlistat (a gastrointestinal lipase inhibitor), lorcaserin (a serotonin 2C receptor agonist), phentermine/topiramate extended-release (a sympathomimetic amine with anoretic effect/mechanism unknown), naltrexone/bupropion (an opioid receptor antagonist/aminoketone antidepressant), and liraglutide (a GLP1 receptor agonist). Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.