In particular, many PD-associated gene products such as α-synuclein [21], PINK1 [22], LRRK2 [23], and DJ-1 [24], as well as parkin [13], have also been reported to associate with lipid rafts, implying that functional alteration of lipid rafts by these proteins may be one of the common pathological mechanisms of PD. The gene discussed is PRKN; the disease is Parkinson disease.