LRRK2 and Parkinson disease: In particular, many PD-associated gene products such as α-synuclein [21], PINK1 [22], LRRK2 [23], and DJ-1 [24], as well as parkin [13], have also been reported to associate with lipid rafts, implying that functional alteration of lipid rafts by these proteins may be one of the common pathological mechanisms of PD.