MPO and acute kidney injury: In 2012, Perianayagam et al. [32] found an association in a primary cohort of AKI patients between the myeloperoxidase (MPO) gene −765 T/C (rs2243828), +9890 A/C (rs2071409), and +2149 T/C (rs2759) polymorphisms and lower urine output as well as the composite outcome of dialysis administration or in-hospital death, and with MPO +157 G/T polymorphism (rs7208693) and more advanced AKI as well as the aforementioned composite outcome.