PNMT and acute kidney injury: Alam et al. [31] found that phenylethanolamine N-methyltransferase (PNMT) gene rs5638 + 1543 G –allele is associated with an increased risk for AKI, and the genotype +1543 G/A is associated with oliguria, whereas PNMT rs876493 -161 A –allele is associated with lower mortality and less circulatory shock.