The MUFA to saturated fatty acid ratio, particularly C16:1/C16:0 and C18:1/C18:0, affects membrane phospholipid composition, and studies have indicated that alteration in this ratio has been involved in multiple MetS-related diseases, such as diabetes and cardiovascular disease [31] Therefore, the activity of SCD-1 is important in MetS states. The gene discussed is SCD; the disease is diabetes mellitus.