To discover potential serum biomarkers for differentiate TLE, XLE and IGE, we tested 14 interictal cytokine concentrations (IL-1b, IL-1Ra, IL-2, IL-4, IL-6, IL-8, IL-10, IFNγ, IL-17a, IFNλ1, IFNλ2, IFNλ3, IFNλ4, and IL-23). This evidence concerns the gene IL1B and idiopathic generalized epilepsy.