MiR-186 overexpression inhibited the expression levels of MDR1 and GST-π mRNA in ovarian cancer cell lines while anti-miR-186 transfection upregulated MDR1 and GST-π expression compared with negative control cells or mock transfected cells (Fig. 5a, p < 0.05). The gene discussed is ABCB1; the disease is ovarian carcinoma.