Moreover, TMV containing EGFRvIII released by more aggressive glioma cells were found to be responsible for the transfer of this receptor to indolent cells, which in turn caused the activation of transforming signaling pathways (MAPK and AKT) and changes in other gene expression (VEGF, Bcl-xL, p27) resulting in morphological transformation [37]. This evidence concerns the gene AKT1 and central nervous system cancer.