ITGAM and nervous system disorder: Similar to the experiment using CCR2 KO BM recipients, CD11c-DTR·CCR2 KO BM recipients that received CD11b+Ly-6Chi monocytes sorted from CD11chi DC-ablated mice showed higher susceptibility to JE than did the recipients of CD11b+Ly-6Chi monocytes sorted from vehicle-treated CD11c-DTR mice, as evaluated by mortality (p = 0.0349) (Fig. S9A), rapid development of neurological disorder (Fig. S9B), and body weight change during JE progression (Fig. S9C).