Notably, the expression levels of TNF-α and CCL2, which showed prominent increases in the CNS during JE progression, were significantly increased in CD11b+Ly-6Chi monocytes infiltrated into the immune-privileged CNS of DC-ablated mice, compared to those of vehicle-treated CD11c-DTR mice (Fig. 3D). The gene discussed is CCL2; the disease is Japanese encephalitis.