Although our results propose early pronounced CNS infiltration of inadequately differentiated CD11b+Ly-6Chi monocytes in the absence of CD11chi DCs, resulting in the induction of severe neuroinflammation and a deleterious role in encephalitis, we did not provide direct evidence as to whether infiltration of inadequately differentiated CD11b+Ly-6Chi monocytes into the immune-privileged CNS played a deleterious or beneficial role in JE progression. Here, ITGAM is linked to encephalitis.