To further understand the precise mechanism of the anti-tumor effect on RCC cells induced by CYP1B1 knockdown, we looked for changes in gene expression in CYP1B1 siRNA-treated and NS siRNA-treated control cells using the Human Cancer Pathway RT2 ProfilerTM PCR Array and the Human Apoptosis RT2 ProfilerTM PCR Array. This evidence concerns the gene CYP1B1 and renal cell carcinoma.