KPNA2 over-expression was significantly correlated with the AJCC stage (p = 0.01), T-classification (p = 0.018), regional lymph node metastasis (p = 0.025), distant metastasis (p = 0.014), and differentiated degree (p = 0.001), while no relationship was found between KPNA2 expression and age, gender, tumor location or vessel invasion status. The gene discussed is KPNA2; the disease is neoplasm.