Serum OPG concentrations were significantly higher in subjects with isolated IFG, isolated IGT, combined IFG and IGT, and newly diagnosed type 2 diabetes compared with concentrations in participants with NGR (2.95, 2.98, 2.96, 3.02 μg/l vs 2.63 μg/l, all p < 0.01), after adjustment for sex, age, BMI, current smoking and current alcohol intake and the family history of diabetes. The gene discussed is TNFRSF11B; the disease is diabetes mellitus.