CXCL8 and Hepatic steatosis: In the present study, CP-induced apparent heptatotoxic (but not lethal) phenomena, which were consistent with previous reports33, 34, were appeared, including elevated liver damage indexes (ALT, AST and ALP) and disturbed inflammatory mediators35, 36 (IL-6, IL-8 and IL-10) in serum, infiltrated inflammatory cells (macrophages) and heavy hepatic steatosis in liver, as well as reduced tendency of body weight.