JRFL gp120 and JRFL pseudovirus have been previously shown not to bind α4β7 or inhibit infection in the presence of mAbs ACT-1 or α4 specific mAb 2B4 [40, 41], while SF162 has been shown to inhibit the binding and infection [41] of the trimers, with the V2 and V3 regions being more accessible to binding ligands. This evidence concerns the gene ITIH4 and infection.