To further understand the potential cellular mechanisms whereby combined therapy of B10G5 and ALT-803 enhances NK functionality, purified mouse splenic NK cells were co-cultured with the murine prostate cancer cell line RM9 overexpressing sMICB (RM9-sMICB) in the presence of IgG, B10G5, ALT-803, or the combination of ALT-803 and B10G5. The gene discussed is GPT; the disease is prostate carcinoma.