Moreover, when B16 melanoma cells were co-injected with C57BL/6 Ly6G+ cells into C57BL/6 mice, similar results were observed that the tumors from 9-HODE-treated lal−/− Ly6G+ cell-injected mice were significantly smaller than those developed in ethanol-treated lal−/− Ly6G+ cell-injected mice at 7, 14 and 21 days post-injection (Figure 1B). This evidence concerns the gene LIPA and melanoma.