Beyond confirming mutations in genes previously identified in BC, we uncovered five frequently altered genes exclusively in recurrent BC including MLL, EP400, PRDM2, ANK3 and CHD5. In particular, four recurrent BCs harbored four distinct non-synonymous SNV in MLL locus in which one mutation located in the typical PHD domain named c.C4437G substitution. The gene discussed is PRDM2; the disease is breast cancer.