In total, we identified 24 significantly mutated genes in 37 BCs (Figure 1 and Supplementary Table 4) including four well-known bladder cancer related genes (TP53 [20, 21], HRAS [22], FGFR3 [22], and PIK3CA [23, 24]). The gene discussed is FGFR3; the disease is urinary bladder carcinoma.