TP53 and Familial prostate cancer: Although it has also been reported that DU145 (mutant p53) and PC3 (p53 null) cells were less sensitive than LNCaP and C4-2 cells expressing functional p53 in response to docetaxel, The reason for the conflict among these conclusions remains unclear while a possile explanation lies in the different passages or variants of prostate cancer cells used by different laboratories.