As many growth factors activate p90RSK in cancer, we evaluated whether RSK1/RSK2 silencing might impair the motile phenotype of ovarian cancer cells induced by Hepatocyte Growth Factor (HGF) that is known also as Scatter Factor, for its ability to trigger cell motility and invasiveness and ultimately to stimulate cell metastatic ability [17, 18]. The gene discussed is RPS6KA3; the disease is ovarian cancer.