SOCS3 and malignant colon neoplasm: For example, HDAC8 has been reported to form corepressor complexes with Stat3 to repress the proapoptotic target gene BMF in colon cancer cells [35], and to activate Jak2/Stat signaling through epigenetic repression of SOCS1 and SOCS3 genes in K562 and HEL erythroleukemia cells [36].