HDAC8 and breast carcinoma: To interrogate the functional relationship between HDAC8 and Notch1, we assessed the protein expression profiles of Notch1 versus HDAC8 in a panel of breast cancer cell lines, including MDA-MB-231, SUM-159, T47D, BT474, HCC1937, MCF-7, SKBR3, MDA-MB-468, and ZR7530 (Figure 3C, left).