AFP and malignant germ cell tumor: Currently, patients are risk stratified using the International Germ Cell Cancer Collaborative Group (IGCCCG) prognostic classification, which is based on histology (seminoma [SEM] versus non-seminoma [NSGCT]), serum marker levels of alpha-fetoprotein (AFP), human chorionic gonadatropin (HCG), and lactate dehydrogenase (LDH), the presence of non-pulmonary visceral metastases, and the site of the primary tumor (gonadal versus mediastinal) [1].