DOX nephropathy models the progressive podocyte depletion, tubulointerstitial inflammation, and the development of glomerulosclerosis similar to the pathogenic changes observed in FSGS.26 Previous studies have demonstrated that blockade of CD40-CD40L signaling via administration of a CD40L antagonistic antibody was effective at mitigating disease.20,27 Our data further support an important role of CD40 in a mouse model of chronic kidney disease and also suggest that renal expression of CD40 has an important role to promote inflammation and disease. This evidence concerns the gene CD40LG and glomerulosclerosis.