KRAS and neoplasm: In light of the new evidence regarding the lack of miR-143/145 functionality in intestinal epithelial cells, one may hypothesize that miR-143/145 may function as a surrogate marker for tumor infiltration with mesenchymal cells rather than repression of target genes, such as KRAS. Thus it would be interesting to see an expression analysis of miR-143/145 using in situ hybridization of CRC tissue microarrays, and examine co-localization with their validated target genes, such KRAS, NKRAS, CTNNG1, ERK and KLF5.