TCF4 and colorectal carcinoma: By using either a bioinformatics approach to discover miRNA transcription start sites within close proximity to TCF4 chromatin occupancy sites [120] or profiling miRNA expression in CRC cells with disrupted CTNNB1/TCF4 activity followed by integration of TCF4 chromatin data [119], roughly 30 TCF4-responsive miRNAs have been identified.