Subsequent gene set enrichment analysis (GSEA) identified a down-regulation of gene sets typical for EWS-FLI1 fusion targets as identified by Zhang and colleagues [31] as well as those for Ewing sarcoma progenitors identified by Riggi et al. [32] (Figure 2D), indicating that JQ1 inhibits EWS-FLI1 expression and thereby similarly inhibits an ES typical expression profile (Supplementary Table S1). Here, FLI1 is linked to Ewing sarcoma.