The sensitivity of KIBRAF cells NSCLC to MEK inhibitors (below) and the fact that activation of oncogenes, including BRAF, paradoxically leads to senescence that depends on the modulation of MEK/ERK signaling [24, 25] led us to examine ERK and MEK activation following treatment with dasatinib in KIBRAF NSCLC cells (H1666, Cal12T) and WTBRAF NSCLC cells (A549, H661) using phosphospecific antibodies (Figure 6A). Here, BRAF is linked to non-small cell lung carcinoma.