INS and type 2 diabetes mellitus: The finding that k5 for the T2DM group was significantly smaller than that for the NGT or IGT groups thus indicated that insulin secretion is reduced in T2DM subjects compared with NGT and IGT subjects, consistent with the result that both simulated and actual AUCIRI10 values for T2DM were smaller than those for the other two groups (Fig 1C and 1D).