ERG and neoplasm: Aims of this exploratory retrospective study, which complies to the recommendations of Early Detection Research Network [10], were: (a) to identify metabolites with different levels in malignant and non-malignant tissue, (b) to correlate these metabolites with conventional clinical-pathological variables (tumor stage and grade and TMPRSS2-ERG (ERG) translocation), and (c) to integrate these metabolites with a targeted protein expression analysis data set in order to identify regulatory or deregulatory mechanisms that were not obvious from a single –omics data set alone.