During its development, maternal hyperglycemia, which reaches the fetuses by facilitated diffusion (Aguilar-Bryan et al., 1995), stimulates overproduction of insulin that interferes with fetal homeostasis, might leading to macrosomia, trauma of the birth canal, twisted shoulder, hypoglycemia, hyperbilirubinemia, hypocalcaemia and polycythemia fetal, neonatal respiratory disorders, blindness, kidney failure, and intrauterine fetal death (O`Sullivan et al., 1973; Larimore and Petrie, 2000). Here, INS is linked to Large for gestational age.