P.Ala4Val and p.Gly85Ser almost always cause rapidly progressive ALS.   6  p.Asp90Ala and p.Leu144Ser are associated with long survival time.12,13 As SOD1 mutations are relatively common among Iranian patients, we were interested to further explore genotype/phenotype correlations of SOD1 mutations. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.