HDAC1 and alpha thalassemia-X-linked intellectual disability syndrome: Previous studies have shown that MeCP2 interacts with a number of proteins involved in chromatin formation or remodeling, including the histone deacetylase enzyme, HDAC1 [10, 11], heterochromatin protein 1 (HP1α) and ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (α-thalassemia/mental retardation, X-linked) [14].