This unique variant has not been reported in either of the Breast Information Core mutation database (research.nhgri.nih.gov/bic/) or the LOVD-Leiden Open Variation Database (chromium.liacs.nl/LOVD2/cancer/home.php?select_db=BRCA1), nor the Exome Aggregation Consortium (ExAC) database (exac.broadinstitute.org). This evidence concerns the gene BRCA1 and cancer.